Differential Pharmacodynamic Effects on Psoriatic Biomarkers by Guselkumab Versus Secukinumab Correlate with Long-Term Efficacy: An ECLIPSE Substudy

• Main Authors: Andrew Blauvelt (Author), Yanqing Chen (Author), Patrick J. Branigan (Author), Xuejun Liu (Author), Samuel DePrimo (Author), Brice E. Keyes (Author), Monica Leung (Author), Steven Fakharzadeh (Author), Ya-Wen Yang (Author), Ernesto J. Muñoz-Elías (Author), James G. Krueger (Author), Richard G. Langley (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IL-23 is a cytokine produced by myeloid cells that drives the T helper 17 pathway and plays an essential role in the pathophysiology of plaque psoriasis. IL-23 activation initiates a cascade of cytokines subsequently inducing the expression of many psoriasis-related proteins. This study aimed to bet...