Enhanced Differentiation Capacity and Transplantation Efficacy of Insulin-Producing Cell Clusters from Human iPSCs Using Permeable Nanofibrous Microwell-Arrayed Membrane for Diabetes Treatment

• Main Authors: In Kyong Shim (Author), Seong Jin Lee (Author), Yu Na Lee (Author), Dohui Kim (Author), Hanse Goh (Author), Jaeseung Youn (Author), Jinah Jang (Author), Dong Sung Kim (Author), Song Cheol Kim (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although pancreatic islet transplantation is a potentially curative treatment for insulin-dependent diabetes, a shortage of donor sources, low differentiation capacity, and transplantation efficacy are major hurdles to overcome before becoming a standard therapy. Stem cell-derived insulin-producing...