Ex Vivo Expansion of Murine MSC Impairs Transcription Factor-Induced Differentiation into Pancreatic β-Cells

• Main Authors: Dario Gerace (Author), Rosetta Martiniello-Wilks (Author), Rosaline Habib (Author), Binhai Ren (Author), Najah Therese Nassif (Author), Bronwyn Anne O'Brien (Author), Ann Margaret Simpson (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Combinatorial gene and cell therapy as a means of generating surrogate β-cells has been investigated for the treatment of type 1 diabetes (T1D) for a number of years with varying success. One of the limitations of current cell therapies for T1D is the inability to generate sufficient quantities of f...