A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent mechanism in neuropathic pain

• Main Authors: Sakamoto Atsuhiro (Author), Ikeda Yumiko (Author), Sakai Atsushi (Author), Toda Shigeru (Author), Suzuki Hidenori (Author)
• Format: Book
• Published: SAGE Publishing, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Local anesthetics alleviate neuropathic pain in some cases in clinical practice, and exhibit longer durations of action than those predicted on the basis of the pharmacokinetics of their blocking effects on voltage-dependent sodium c...