2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

Small interfering RNAs (siRNAs) have the potential to treat a broad range of diseases. siRNAs need to be extensively chemically modified to improve their bioavailability, safety, and stability in vivo. However, chemical modifications variably impact target silencing for different siRNA sequences, ma...

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Main Authors: Sarah M. Davis (Author), Jacquelyn Sousa (Author), Lorenc Vangjeli (Author), Matthew R. Hassler (Author), Dimas Echeverria (Author), Emily Knox (Author), Anton A. Turanov (Author), Julia F. Alterman (Author), Anastasia Khvorova (Author)
Format: Book
Published: Elsevier, 2020-09-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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