2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

• मुख्य लेखकों: Sarah M. Davis (लेखक), Jacquelyn Sousa (लेखक), Lorenc Vangjeli (लेखक), Matthew R. Hassler (लेखक), Dimas Echeverria (लेखक), Emily Knox (लेखक), Anton A. Turanov (लेखक), Julia F. Alterman (लेखक), Anastasia Khvorova (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Small interfering RNAs (siRNAs) have the potential to treat a broad range of diseases. siRNAs need to be extensively chemically modified to improve their bioavailability, safety, and stability in vivo. However, chemical modifications variably impact target silencing for different siRNA sequences, ma...