Iron as a Therapeutic Target in <i>HFE</i>-Related Hemochromatosis: Usual and Novel Aspects

• Autori principali: Olivier Loréal (Autore), Thibault Cavey (Autore), François Robin (Autore), Moussa Kenawi (Autore), Pascal Guggenbuhl (Autore), Pierre Brissot (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2018-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Genetic hemochromatosis is an iron overload disease that is mainly related to the <i>C282Y</i> mutation in the <i>HFE</i> gene. This gene controls the expression of hepcidin, a peptide secreted in plasma by the liver and regulates systemic iron distribution. Homozygous <i&...