Glabridin Prevents Doxorubicin-Induced Cardiotoxicity Through Gut Microbiota Modulation and Colonic Macrophage Polarization in Mice

• Main Authors: Keqing Huang (Author), Yanzhuo Liu (Author), Honglin Tang (Author), Miao Qiu (Author), Chenhong Li (Author), Chenfan Duan (Author), Chenlong Wang (Author), Jing Yang (Author), Xiaoyang Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The chemotherapeutic drug doxorubicin (DOX) provokes a dose-related cardiotoxicity. Thus, there is an urgent need to identify the underlying mechanisms and develop strategies to overcome them. Here we demonstrated that glabridin (GLA), an isoflavone from licorice root, prevents DOX-induced cardiotox...