EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers

• Main Authors: Raquel Luna Yolba (Author), Virgile Visentin (Author), Caroline Hervé (Author), Johanna Chiche (Author), Jean‐Ehrland Ricci (Author), Jérôme Méneyrol (Author), Michaël R. Paillasse (Author), Nathalie Alet (Author)
• Format: Book
• Published: Wiley, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Targeting the first protein complex of the mitochondrial electron transport chain (MC1) in cancer has become an attractive therapeutic approach in the recent years, given the metabolic vulnerabilities of cancer cells. The anticancer effect exerted by the pleiotropic drug metformin and the a...