Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats

• Main Authors: Masatsugu Ohara (Author), Shunsuke Ohnishi (Author), Hidetaka Hosono (Author), Koji Yamamoto (Author), Kohei Yuyama (Author), Hideki Nakamura (Author), Qingjie Fu (Author), Osamu Maehara (Author), Goki Suda (Author), Naoya Sakamoto (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. There are no approved drug treatments for liver fibrosis and nonalcoholic steatohepatitis (NASH), an advanced stage of fibrosis which has rapidly become a major cause of cirrhosis. Therefore, development of anti-inflammatory and antifibrotic therapies is desired. Mesenchymal stem cell- (...