Effects of STING stimulation on macrophages: STING agonists polarize into "classically" or "alternatively" activated macrophages?

• Autores principales: Takayuki Ohkuri (Autor), Akemi Kosaka (Autor), Toshihiro Nagato (Autor), Hiroya Kobayashi (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2018-02-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Stimulator of interferon genes (STING) was defined as an important molecule for promoting antitumor immunity through mediating type I interferon (IFN) production by sensing its ligands such as cyclic GMP-AMP (cGAMP). Our recent study indeed demonstrated that intratumoral injection of cGAMP showed ef...