Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors

• Main Authors: Nicola J. Mason (Author), Nicholas Chester (Author), Ailian Xiong (Author), Antonia Rotolo (Author), Ying Wu (Author), Sho Yoshimoto (Author), Patrick Glassman (Author), Gayathri Gulendran (Author), Don L. Siegel (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The immune checkpoint inhibitor (ICI) ipilimumab has revolutionized the treatment of patients with different cancer histologies, including melanoma, renal cell carcinoma, and non-small cell lung carcinoma. However, only a subset of patients shows dramatic clinical responses to treatment. Despite int...