Investigation of the Effects of a Novel NOX2 Inhibitor, GLX7013170, against Glutamate Excitotoxicity and Diabetes Insults in the Retina

• Ngā kaituhi matua: Stavroula Dionysopoulou (Author), Per Wikstrom (Author), Erik Walum (Author), Spiros Georgakis (Author), Kyriaki Thermos (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2024-03-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Glutamate excitotoxicity and oxidative stress represent two major pathological mechanisms implicated in retinal disorders. In Diabetic Retinopathy (DR), oxidative stress is correlated to NADPH oxidase (NOX), a major source of Reactive Oxygen Species (ROS), and glutamate metabolism impairments. This...