Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Egile Nagusiak: Huimin Ji (Egilea), Hongliang Dong (Egilea), Yuejiao Lan (Egilea), Yuqian Bi (Egilea), Xuan Gu (Egilea), Yongyue Han (Egilea), Chongyang Yang (Egilea), Minghan Cheng (Egilea), Jian Gao (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...