Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy.

• Main Authors: Willem S Lexmond (Author), Paul A Rufo (Author), Edda Fiebiger (Author), Wayne I Lencer (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Morbidity and mortality from acute diarrheal disease remains high, particularly in developing countries and in cases of natural or man-made disasters. Previous work has shown that the small molecule clotrimazole inhibits intestinal Cl- secretion by blocking both cyclic nucleotide- and Ca(2+)-gated K...