Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs

• 主要な著者: Minoru Ishikawa (著者), Shusuke Tomoshige (著者), Yosuke Demizu (著者), Mikihiko Naito (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2020-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

New therapeutic modalities are needed to address the problem of pathological but undruggable proteins. One possible approach is the induction of protein degradation by chimeric drugs composed of a ubiquitin ligase (E3) ligand coupled to a ligand for the target protein. This article reviews chimeric...