Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease

• Main Authors: Mengfang Wu (Author), Tian Xia (Author), Yaran Li (Author), Tianfa Wang (Author), Shijia Yang (Author), Jinchao Yu (Author), Qiaoyan Liang (Author), Teng Shen (Author), Min Yu (Author), Bing Zhao (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiovascular disease is the leading cause of global mortality, with anticoagulant therapy being the main prevention and treatment strategy. Recombinant hirudin (r-hirudin) is a direct thrombin inhibitor that can potentially prevent thrombosis via subcutaneous (SC) and intravenous (IV) administrati...