Triglyceride-mimetic prodrugs of scutellarin enhance oral bioavailability by promoting intestinal lymphatic transport and avoiding first-pass metabolism

• Main Authors: Xinran Wang (Author), Cai Zhang (Author), Ning Han (Author), Juyuan Luo (Author), Shuofeng Zhang (Author), Chunguo Wang (Author), Zhanhong Jia (Author), Shouying Du (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The intestinal capillary pathway is the most common way to absorb oral drugs, but for drugs with poor solubility and permeability and high first-pass metabolism, this pathway is very inefficient. Although intestinal lymphatic transport of lipophilic drugs or prodrugs is a promising strategy to impro...