Deriving mechanism‐based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin

• Main Authors: Undine Falkenhagen (Author), Jane Knöchel (Author), Charlotte Kloft (Author), Wilhelm Huisinga (Author)
• 格式: 圖書
• 出版: Wiley, 2023-04-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Quantitative systems pharmacology (QSP) models integrate comprehensive qualitative and quantitative knowledge about pharmacologically relevant processes. We previously proposed a first approach to leverage the knowledge in QSP models to derive simpler, mechanism‐based pharmacodynamic (PD) m...