Improving cellular uptake and bioavailability of periplocymarin-linoleic acid prodrug by combining PEGylated liposome

Periplocymarin (PPM), a cardiac glycoside isolated from Cortex periplocae, has a strong anti-tumor effect against various cancer cells. However, cardiotoxicity and rapid metabolism hinder its clinical applications. In this study, small molecule prodrug was integrated into PEGylated liposome to impro...

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Main Authors: Huiyun Zhang (Author), Shunru Wei (Author), Yu Zhang (Author), Anran Pan (Author), Michael Adu-Frimpong (Author), Congyong Sun (Author), Gang Qi (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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