Simultaneous Determination of Five Alkaloids by HPLC-MS/MS Combined With Micro-SPE in Rat Plasma and Its Application to Pharmacokinetics After Oral Administration of Lotus Leaf Extract

• Hoofdauteurs: Shuhan Zou (Auteur), Yuanyuan Ge (Auteur), Xuanhao Chen (Auteur), Jin Li (Auteur), Xuejing Yang (Auteur), Hui Wang (Auteur), Xiumei Gao (Auteur), Yan-xu Chang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

An environment-friendly and efficient method for simultaneous determination of five alkaloids (nunciferine, O-nornuciferin, liriodenine, armepavine, and pronuciferine) in rat plasma was established by HPLC-MS/MS associated with micro-solid phase extraction (micro-SPE). The plasma sample was pretreat...