Simultaneous Determination of Five Alkaloids by HPLC-MS/MS Combined With Micro-SPE in Rat Plasma and Its Application to Pharmacokinetics After Oral Administration of Lotus Leaf Extract

Simultaneous Determination of Five Alkaloids by HPLC-MS/MS Combined With Micro-SPE in Rat Plasma and Its Application to Pharmacokinetics After Oral Administration of Lotus Leaf Extract

An environment-friendly and efficient method for simultaneous determination of five alkaloids (nunciferine, O-nornuciferin, liriodenine, armepavine, and pronuciferine) in rat plasma was established by HPLC-MS/MS associated with micro-solid phase extraction (micro-SPE). The plasma sample was pretreat...

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Main Authors: Shuhan Zou (Author), Yuanyuan Ge (Author), Xuanhao Chen (Author), Jin Li (Author), Xuejing Yang (Author), Hui Wang (Author), Xiumei Gao (Author), Yan-xu Chang (Author)
Format: Book
Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
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