Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice

• Main Authors: Susan M. Motch Perrine (Author), Meng Wu (Author), Nicholas B. Stephens (Author), Divya Kriti (Author), Harm van Bakel (Author), Ethylin Wang Jabs (Author), Joan T. Richtsmeier (Author)
• Format: Book
• Published: The Company of Biologists, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One diagnostic feature of craniosynostosis syndromes is mandibular dysgenesis. Using three mouse models of Apert, Crouzon and Pfeiffer craniosynostosis syndromes, we investigated how embryonic development of the mandible is affected by fibroblast growth factor receptor 2 (Fgfr2) mutations. Quantitat...