Sphingosylphosphorylcholine Antagonizes Proton-Sensing Ovarian Cancer G-Protein-Coupled Receptor 1 (OGR1)-Mediated Inositol Phosphate Production and cAMP Accumulation

• Main Authors: Chihiro Mogi (Author), Hideaki Tomura (Author), Masayuki Tobo (Author), Ju-Qiang Wang (Author), Alatangaole Damirin (Author), Junko Kon (Author), Mayumi Komachi (Author), Kinji Hashimoto (Author), Koichi Sato (Author), Fumikazu Okajima (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ovarian cancer G-protein-coupled receptor 1 (OGR1), previously proposed as a receptor for sphingosylphosphorylcholine (SPC), has recently been identified as a proton-sensing or extracellular pH-responsive G-protein-coupled receptor stimulating inositol phosphate production, reflecting the activation...