Significance of Matrix Metalloproteinase-9 Inhibition by Imidapril for Prevention of Abdominal Aortic Aneurysms in Angiotensin II Type 1 Receptor-Knockout Mice

• المؤلفون الرئيسيون: Shinji Takai (مؤلف), Denan Jin (مؤلف), Daisuke Yamamoto (مؤلف), Zhong-Lian Li (مؤلف), Yoshinori Otsuki (مؤلف), Mizuo Miyazaki (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2013-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

To clarify the matrix metalloproteinase (MMP)-9 inhibitory effect of an angiotensin-converting enzyme (ACE) inhibitor in vivo, we evaluated the effect of an ACE inhibitor against elastase-induced abdominal aortic aneurysm (AAA) progression in mice. Molecular models showed that imidapril bound direct...