Novel Population Pharmacokinetic Approach to Explain the Differences between Cystic Fibrosis Patients and Healthy Volunteers via Protein Binding

• Main Authors: Nirav R. Shah (Author), Jürgen B. Bulitta (Author), Martina Kinzig (Author), Cornelia B. Landersdorfer (Author), Yuanyuan Jiao (Author), Dhruvitkumar S. Sutaria (Author), Xun Tao (Author), Rainer Höhl (Author), Ulrike Holzgrabe (Author), Frieder Kees (Author), Ulrich Stephan (Author), Fritz Sörgel (Author)
• Format: Book
• Published: MDPI AG, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacokinetics in patients with cystic fibrosis (CF) has long been thought to differ considerably from that in healthy volunteers. For highly protein bound β-lactams, profound pharmacokinetic differences were observed between comparatively morbid patients with CF and healthy volunteers. These...