Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol.

• Main Authors: Sarah Hendrickx (Author), Raquel Andrea Inocêncio da Luz (Author), Vasundhra Bhandari (Author), Kristel Kuypers (Author), Craig D Shaw (Author), Julien Lonchamp (Author), Poonam Salotra (Author), Katharine Carter (Author), Shyam Sundar (Author), Suman Rijal (Author), Jean-Claude Dujardin (Author), Paul Cos (Author), Louis Maes (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paromomycin (PMM) has recently been introduced for treatment of visceral leishmaniasis in India. Although no clinical resistance has yet been reported, proactive vigilance should be warranted. The present in vitro study compared the outcome and stability of experimental PMM-resistance induction on p...