Natural Potent NAAA Inhibitor Atractylodin Counteracts LPS-Induced Microglial Activation

• Main Authors: Longhe Yang (Author), Chunyan Ji (Author), Yitian Li (Author), Fan Hu (Author), Fang Zhang (Author), Haiping Zhang (Author), Long Li (Author), Jie Ren (Author), Zhaokai Wang (Author), Yan Qiu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

N-acylethanolamine-hydrolyzing acid amidase (NAAA) is a lysosomal enzyme that inhibits the degradation of palmitoylethanolamide (PEA), an endogenous lipid that induces analgesic, anti-inflammation, and anti-multiple sclerosis through PPARα activation. Only a few potent NAAA inhibitors have been repo...