Natural Potent NAAA Inhibitor Atractylodin Counteracts LPS-Induced Microglial Activation

• Главные авторы: Longhe Yang (Автор), Chunyan Ji (Автор), Yitian Li (Автор), Fan Hu (Автор), Fang Zhang (Автор), Haiping Zhang (Автор), Long Li (Автор), Jie Ren (Автор), Zhaokai Wang (Автор), Yan Qiu (Автор)
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• Опубликовано: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Предметы: article
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N-acylethanolamine-hydrolyzing acid amidase (NAAA) is a lysosomal enzyme that inhibits the degradation of palmitoylethanolamide (PEA), an endogenous lipid that induces analgesic, anti-inflammation, and anti-multiple sclerosis through PPARα activation. Only a few potent NAAA inhibitors have been repo...