Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation

• Main Authors: Jean-Baptiste Woillard (Author), Michel Mourad (Author), Michael Neely (Author), Arnaud Capron (Author), Ron H. van Schaik (Author), Teun van Gelder (Author), Nuria Lloberas (Author), Dennis A. Hesselink (Author), Pierre Marquet (Author), Vincent Haufroid (Author), Laure Elens (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Par...