Novel benzamido derivatives as PTP1B inhibitors with anti-hyperglycemic and lipid-lowering efficacy

• Main Authors: Yanbo Tang (Author), Xiaolin Zhang (Author), Zheng Chen (Author), Wenwen Yin (Author), Guanglei Nan (Author), Jinying Tian (Author), Fei Ye (Author), Zhiyan Xiao (Author)
• Format: Book
• Published: Elsevier, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on a non-competitive and selective PTP1B inhibitor reported by us previously, thirty-nine benzamido derivatives were designed and synthesized as novel PTP1B inhibitors. Among them, twelve compounds exhibited IC50 values at micromolar level against human recombinant PTP1B, and most of them exhi...