Engineered targeting tLyp-1 exosomes as gene therapy vectors for efficient delivery of siRNA into lung cancer cells

• Main Authors: Jing Bai (Author), Jialun Duan (Author), Rui Liu (Author), Yafei Du (Author), Qian Luo (Author), Yinuo Cui (Author), Zhanbo Su (Author), Jiarui Xu (Author), Ying Xie (Author), Wanliang Lu (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Natural exosomes can express specific proteins and carbohydrate molecules on the surface and hence have demonstrated the great potentials for gene therapy of cancer. However, the use of natural exosomes is restricted by their low transfection efficiency. Here, we report a novel targeting tLyp-1 exos...