Systematic analysis of the intersection of disease mutations with protein modifications

• Principais autores: Claire M. Simpson (Autor), Bin Zhang (Autor), Peter V. Hornbeck (Autor), Florian Gnad (Autor)
• Formato: Livro
• Publicado em: BMC, 2019-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Perturbed posttranslational modification (PTM) landscapes commonly cause pathological phenotypes. The Cancer Genome Atlas (TCGA) project profiles thousands of tumors allowing the identification of spontaneous cancer-driving mutations, while Uniprot and dbSNP manage genetic diseas...