Metabonomics reveals drastic changes in anti-inflammatory/pro-resolving polyunsaturated fatty acids-derived lipid mediators in leprosy disease.

• Main Authors: Julio J Amaral (Author), Luis Caetano M Antunes (Author), Cristiana S de Macedo (Author), Katherine A Mattos (Author), Jun Han (Author), Jingxi Pan (Author), André L P Candéa (Author), Maria das Graças M O Henriques (Author), Marcelo Ribeiro-Alves (Author), Christoph H Borchers (Author), Euzenir N Sarno (Author), Patrícia T Bozza (Author), B Brett Finlay (Author), Maria Cristina V Pessolani (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite considerable efforts over the last decades, our understanding of leprosy pathogenesis remains limited. The complex interplay between pathogens and hosts has profound effects on host metabolism. To explore the metabolic perturbations associated with leprosy, we analyzed the serum metabolome o...