Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells

• Egile Nagusiak: Surabhi Surabhi (Egilea), Lana H. Jachmann (Egilea), Patience Shumba (Egilea), Gerhard Burchhardt (Egilea), Sven Hammerschmidt (Egilea), Nikolai Siemens (Egilea)
• Formatua: Liburua
• Argitaratua: Karger Publishers, 2021-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Epithelial cells play a crucial role in detection of the pathogens as well as in initiation of the host immune response. Streptococcus pneumoniae (pneumococcus) is a typical colonizer of the human nasopharynx, which can disseminate to the lower respiratory tract and subsequently cause severe invasiv...