Self-Assembled Lipoplexes of Short Interfering RNA (siRNA) Using Spermine-Based Fatty Acid Amide Guanidines: Effect on Gene Silencing Efficiency

Four guanidine derivatives of N4,N9-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18 unsaturated chains, N1,N12-diamidino-N4,N9-dioleoylspermine and N1,N12-diamidino-N...

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Main Authors: Abdelkader A. Metwally (Author), Ian S. Blagbrough (Author)
Format: Book
Published: MDPI AG, 2011-07-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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