Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway

• Main Authors: Renjing Yang (Author), Chunchun Du (Author), Ting Cao (Author), Guanghui Wang (Author), Xin Jiang (Author), Jun Gao (Author), Ting Lin (Author), Cuiling Sun (Author), Rong Ding (Author), Wenjing Tian (Author), Haifeng Chen (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ursodeoxycholic acid (UDCA) is a first-line clinical drug for the treatment of liver diseases. U12, a derivative of UDCA, showed effective anti-hepatoma activities in previous works. However, the low polarity and large doses limited the druglikeness of U12. In this study, the structural modification...