Dynamic phenotypic shifts and M2 receptor downregulation in bladder smooth muscle cells induced by mirabegron

• Váldodahkkit: A. E. Muderrisoglu (Dahkki), A. Ciotkowska (Dahkki), B. Rutz (Dahkki), S. Hu (Dahkki), S. Qian (Dahkki), A. Tamalunas (Dahkki), C. G. Stief (Dahkki), M. Hennenberg (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

IntroductionMirabegron is available for treatment of overactive bladder (OAB). However, mechanisms underlying symptom improvements and long-term effects on bladder smooth muscle cells are uncertain. Contractility and growth of bladder smooth muscle contribute to OAB, and depend on smooth muscle phen...