Induction of Oxidative Stress and Ferroptosis in Triple-Negative Breast Cancer Cells by Niclosamide via Blockade of the Function and Expression of SLC38A5 and SLC7A11

• Autori principali: Marilyn Mathew (Autore), Sathish Sivaprakasam (Autore), Gunadharini Dharmalingam-Nandagopal (Autore), Souad R. Sennoune (Autore), Nhi T. Nguyen (Autore), Valeria Jaramillo-Martinez (Autore), Yangzom D. Bhutia (Autore), Vadivel Ganapathy (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2024-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The amino acid transporters SLC38A5 and SLC7A11 are upregulated in triple-negative breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and therefore activates mTOR signaling and induces epigenetic modifications. SLC7A11 transports cystine and increases the cellular le...