Induction of Oxidative Stress and Ferroptosis in Triple-Negative Breast Cancer Cells by Niclosamide via Blockade of the Function and Expression of SLC38A5 and SLC7A11

Induction of Oxidative Stress and Ferroptosis in Triple-Negative Breast Cancer Cells by Niclosamide via Blockade of the Function and Expression of SLC38A5 and SLC7A11

The amino acid transporters SLC38A5 and SLC7A11 are upregulated in triple-negative breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and therefore activates mTOR signaling and induces epigenetic modifications. SLC7A11 transports cystine and increases the cellular le...

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Main Authors: Marilyn Mathew (Author), Sathish Sivaprakasam (Author), Gunadharini Dharmalingam-Nandagopal (Author), Souad R. Sennoune (Author), Nhi T. Nguyen (Author), Valeria Jaramillo-Martinez (Author), Yangzom D. Bhutia (Author), Vadivel Ganapathy (Author)
Format: Book
Published: MDPI AG, 2024-02-01T00:00:00Z.
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3rd Floor Main Library

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