Synthesis of silymarin−selenium nanoparticle conjugate and examination of its biological activity in vitro

• Main Authors: Sergey Staroverov (Author), Sergey Kozlov (Author), Alexander Fomin (Author), Konstantin Gabalov (Author), Vitaliy Khanadeev (Author), Dmitry Soldatov (Author), Ivan Domnitsky (Author), Lev Dykman (Author), Sergey V. Akchurin (Author), Olga Guliy (Author)
• Format: Book
• Published: International Association of Physical Chemists (IAPC), 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Silymarin (Sil) was conjugated to selenium nanoparticles (SeNPs) to increase Sil bioavailability. The conjugates were monodisperse; the average diameter of the native SeNPs was ~ 20-50 ± 1.5 nm, whereas that of the conjugates was 30-50 ± 0.5 nm. The use of SeNPs to increase the bioavailability of Sy...