Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine

• Hauptverfasser: Liping Ma (Verfasst von), Shijie Wei (Verfasst von), Bei Yang (Verfasst von), Wei Ma (Verfasst von), Xiuli Wu (Verfasst von), Hongyan Ji (Verfasst von), Hong Sui (Verfasst von), Jing Chen (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Context: CYP3A4 and P-gp together form a highly efficient barrier for orally absorbed drugs and always share the same substrates. Our previous work revealed that chrysosplenetin (CHR) significantly augmented the rat plasma level and anti-malarial efficacy of artemisinin (ART), partially due to the u...