The dimerization of Δ9-tetrahydrocannabinolic acid A (THCA-A)

• Main Authors: Arben Cuadari (Author), Federica Pollastro (Author), Juan D. Unciti-Broceta (Author), Diego Caprioglio (Author), Alberto Minassi (Author), Annalisa Lopatriello (Author), Eduardo Muñoz (Author), Orazio Taglialatela-Scafati (Author), Giovanni Appendino (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The renewed interest in dimeric salicylates as broad-spectrum anti-inflammatory and anti-diabetic agents provided a rationale to investigate the dimerization of the substituted salicylate Δ9-tetrahydrocannabinolic acid (THCA-A, 3a) as a strategy to solve its instability to decarboxylation and to gen...