Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats

• Autori principali: Xinghui Han (Autore), Yuanyuan He (Autore), Gulan Zeng (Autore), Yonghong Wang (Autore), Wen Sun (Autore), Junchao Liu (Autore), Yanyan Sun (Autore), Jian Yu (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2017-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadot...