Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients

• Main Authors: Hitoshi Kawasuji (Author), Yasuhiro Tsuji (Author), Chika Ogami (Author), Kou Kimoto (Author), Akitoshi Ueno (Author), Yuki Miyajima (Author), Koyomi Kawago (Author), Ippei Sakamaki (Author), Yoshihiro Yamamoto (Author)
• Format: Book
• Published: BMC, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Linezolid is administered as a fixed dose to all patients despite evidence of overexposure and thrombocytopenia in renal impairment. The aims of this study were to evaluate the risk of thrombocytopenia and the utility of therapeutic drug monitoring (TDM), and to propose alternate...