HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer

• Main Authors: Xiaodan Sun (Author), Fen Tang (Author), Qian Guo (Author), Yiwen Liu (Author), Yiqing He (Author), Yan Du (Author), Feng Gao (Author), Guoliang Zhang (Author), Cuixia Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of endocrine resistance is a major clinical problem in estrogen receptor-positive (ER+) breast cancer (BrCa) treatment, in which how cancer cells acquire resistance remains obscure. Hyaluronan synthase 2 (HAS2) is the most critical synthase in producing hyaluronan and is well known f...