Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

• Main Authors: Jeffry Adiwidjaja (Author), Alan V. Boddy (Author), Andrew J. McLachlan (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Fag: article
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Long-term use of imatinib is effective and well-tolerated in children with chronic myeloid leukaemia (CML) yet defining an optimal dosing regimen for imatinib in younger patients is a challenge. The potential interactions between imatinib and coadministered drugs in this "special" populati...