Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells

• Main Authors: Liyun Niu (Author), Huiyu Zhou (Author), Yueru Lian (Author), Ya Gao (Author), Yulu Liu (Author), Ruolan Gu (Author), Zhuona Wu (Author), Xiaoxia Zhu (Author), Hui Gan (Author), Zhiyun Meng (Author), Guifang Dou (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PEP06 is a novel endostatin-Arg-Gly-Asp-Arg-Gly-Asp (RGDRGD) 30-amino-acid polypeptide featuring a terminally fused RGDRGD hexapeptide at the N terminus. The active endostatin fragment of PEP06 directly targets tumor cells and exerts an antitumoral effect. However, little is known about the kinetics...