Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling

• Main Authors: Dexiang Liu (Author), Xuemei Bai (Author), Weiwei Ma (Author), Danqing Xin (Author), Xili Chu (Author), Hongtao Yuan (Author), Jie Qiu (Author), HongFei Ke (Author), Sen Yin (Author), Wenqiang Chen (Author), Zhen Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purmorphamine (PUR), an agonist of the Smoothened (Smo) receptor, has been shown to function as a neuroprotectant in acute experimental ischemic stroke. Its role in hypoxic-ischemic (HI) brain injury in neonatal mice remains unknown. Here we show that PUR attenuated acute brain injury, with a decrea...