Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling

• প্রধান লেখক: Dexiang Liu (লেখক), Xuemei Bai (লেখক), Weiwei Ma (লেখক), Danqing Xin (লেখক), Xili Chu (লেখক), Hongtao Yuan (লেখক), Jie Qiu (লেখক), HongFei Ke (লেখক), Sen Yin (লেখক), Wenqiang Chen (লেখক), Zhen Wang (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Purmorphamine (PUR), an agonist of the Smoothened (Smo) receptor, has been shown to function as a neuroprotectant in acute experimental ischemic stroke. Its role in hypoxic-ischemic (HI) brain injury in neonatal mice remains unknown. Here we show that PUR attenuated acute brain injury, with a decrea...