A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists

• मुख्य लेखकों: Kendall L. Mores (लेखक), Benjamin R. Cummins (लेखक), Robert J. Cassell (लेखक), Richard M. van Rijn (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop opioids that signal primarily via G protein activation and do not, or only very weakly, recruit beta-arrestin. Devel...