A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists

• Main Authors: Kendall L. Mores (Author), Benjamin R. Cummins (Author), Robert J. Cassell (Author), Richard M. van Rijn (Author)
• 格式: 圖書
• 出版: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop opioids that signal primarily via G protein activation and do not, or only very weakly, recruit beta-arrestin. Devel...