Temporal and spatially controlled APP transgene expression using Cre-dependent alleles

• প্রধান লেখক: Emily J. Koller (লেখক), Melissa Comstock (লেখক), Jonathan C. Bean (লেখক), Gabriel Escobedo (লেখক), Kyung-Won Park (লেখক), Joanna L. Jankowsky (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: The Company of Biologists, 2022-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Although a large number of mouse models have been made to study Alzheimer's disease, only a handful allow experimental control over the location or timing of the protein being used to drive pathology. Other fields have used the Cre and the tamoxifen-inducible CreER driver lines to achieve preci...