Temporal and spatially controlled APP transgene expression using Cre-dependent alleles

• Main Authors: Emily J. Koller (Author), Melissa Comstock (Author), Jonathan C. Bean (Author), Gabriel Escobedo (Author), Kyung-Won Park (Author), Joanna L. Jankowsky (Author)
• Format: Book
• Published: The Company of Biologists, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although a large number of mouse models have been made to study Alzheimer's disease, only a handful allow experimental control over the location or timing of the protein being used to drive pathology. Other fields have used the Cre and the tamoxifen-inducible CreER driver lines to achieve preci...