SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells

• Main Authors: Oladapo E. Olaniru (Author), Jordan Cheng (Author), Julia Ast (Author), Anastasia Arvaniti (Author), Patricio Atanes (Author), Guo C. Huang (Author), Aileen J.F. King (Author), Peter M. Jones (Author), Johannes Broichhagen (Author), David J. Hodson (Author), Shanta J. Persaud (Author)
• Format: Bog
• Udgivet: Elsevier, 2021-11-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Objective: Members of the adhesion G protein-coupled receptor (aGPCR) subfamily are important actors in metabolic processes, with GPR56 (ADGRG1) emerging as a possible target for type 2 diabetes therapy. GPR56 can be activated by collagen III, its endogenous ligand, and by a synthetic seven amino-ac...