Oligomannuronate prevents mitochondrial dysfunction induced by IAPP in RINm5F islet cells by inhibition of JNK activation and cell apoptosis

• Main Authors: Xi Liu (Author), Qiong Li (Author), Xiaolei Cheng (Author), Zhichun Liu (Author), Xiaoliang Zhao (Author), Shuai Zhang (Author), Guangli Yu (Author), Xia Zhao (Author), Jiejie Hao (Author)
• Format: Book
• Published: BMC, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Oligomannuronates (OM) are natural products from alginate that is frequently used as food supplement. The aim of this study was to investigate the in vitro protective effects of OM on RINm5F cells against human Islet amyloid polypeptide (IAPP) induced mitochondrial dysfunction, a...